What invalidating breast cancer gene patents implies Porndating netherlands


29-May-2020 17:50

In a further aspect, the tumor antigen is (a) the amino acid residues of the 12 times the wild-type Ras protein mutated position contrast, the peptide including at least 8 to 16-position of the Ras protein;본 발명의 또 다른 구체예는 Ras 아미노산 서열 중 73번 위치에서의 프롤린(P73), 74번 위치에서의 트레오닌(T74), 75번 위치에서의 글라이신(G75), 77번 위치에서의 글라이신(G77) 및/또는 78번 위치에서의 페닐알라닌(F78)이 돌연변이된, Ras (H-Ras, N-Ras 또는 K-Ras)를 코딩하는 핵산 서열의 5개 이상의 연속 아미노산을 포함하는 단리된 핵산 분자에 관한 것이다.

Another embodiment of the present invention is glycine in Ras amino acid sequence of the 73 proline (P73) in a position, threonine (T74) at the 74-position, glycine (G75) at the 75-position, 77-position (G77 ) and / or a phenylalanine (F78) at the 78-position mutation, Ras (H-Ras, N-Ras, or a nucleic acid molecule is isolated comprising a continuous amino acid five or more of the nucleic acid sequence encoding a K-Ras) It relates.

In one aspect, the amino acid sequence is the SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: for the glutamic acid of No.

76 position of the 13 non-SEQ ID NO: by substitution of the glutamic acid amino acid 3, any one of SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 13 and one is differentiated.

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In one aspect, the nucleic acid sequence level of a nucleic acid sequence encoding the mutated Ras protein is brought into contact with the nucleic acid isolated from the selective primer or probe and the test sample which binds to the nucleic acid sequence encoding the mutated Ras protein, encoding the mutated Ras protein It is determined by detecting whether the coupling by which the primer or probe.

Another embodiment of the present invention have a cancer, or in an animal at risk of cancer occurs, the wild-type amino acid sequence and related to the wild-type K-ras, N-ras or H-ras amino acid by mutation of at least 76-position sequence and It is directed to a method for preventing or treating cancer which comprises administering a compound that inhibits the expression of the mutated Ras protein containing the amino acid sequence distinct.본 발명의 또다른 구체예는 암을 가지고 있거나 암이 발생할 위험이 있는 동물에서, 야생형 아미노산 서열과 관련하여 적어도 76번 위치의 돌연변이에 의해 야생형 K-ras, N-ras 또는 H-ras 아미노산 서열과는 구별되는 아미노산 서열을 포함하는 돌연변이 Ras 단백질의 GTP 가수분해를 개시 또는 촉발시키는 화합물을 투여하는 것을 포함하는 암의 예방 또는 치료 방법에 관한 것이다.

Another embodiment of the present invention have a cancer, or in an animal at risk of cancer occurs, the wild-type amino acid sequence and related to the wild-type K-ras, N-ras or H-ras amino acid by mutation of at least 76-position sequence and It is directed to a method for preventing or treating cancer which comprises administering a compound to initiate or trigger the GTP hydrolysis of the mutant Ras proteins comprising an amino acid sequence that is distinct.

Another embodiment of the present invention have a cancer in an animal or in the risk of cancer caused, to a method for preventing or treating cancer which comprises administering an above-described any vaccine.

Another embodiment of the present invention have a cancer, or cancer in the at risk animal occurs, let the above-described random aptamer, the above-described random si RNA, Lai any of the above techniques of, or the above-described random It relates to a method of preventing or treating cancer which comprises administering an antisense nucleic acid molecule.본 발명의 또다른 구체예는암을 가지고 있거나 암이 발생할 위험이 있는 동물에서, 야생형 아미노산 서열과 관련하여 적어도 76번 위치의 돌연변이에 의해 야생형 K-ras, N-ras 또는 H-ras 아미노산 서열과는 구별되는 아미노산 서열을 포함하는 돌연변이 Ras 단백질의 발현을 저해하는 화합물을 투여하는 것을 포함하는 암의 예방 또는 치료 방법에 관한 것이다.

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