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Sodium Bicarbonate, USP is chemically designated Na HCO3, a white crystalline powder soluble in water.
Water for Injection, USP is chemically designated H2O.
When smaller doses are required, the unused portion should be discarded with the entire unit.
Sodium bicarbonate, 84 mg is equal to one milliequivalent each of Na and HCO3¯.
In a healthy adult with normal kidney function, practically all the glomerular filtered bicarbonate ion is reabsorbed; less than 1% is excreted in the urine.
Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis.
The subsequent goal is to increase the bicarbonate level to 15 meq/L over the next 24 hours. Over the subsequent hours, the bicarbonate which was originally administered will be taken up into cells.
Koda-Kimble et al: Replace 50% over 3 to 4 hours and the reminder over 24 hours. In addition, the elevation of systemic p H decreases the compensatory ventilatory response. Since the distribution of bicarbonate is about 50% of lean body weight, ... "Primary goal in treating metabolic acidosis is reversal of the underlying process. It is important to correct the underlying cause and to administer IV bicarbonate to maintain a p H Replace 50% over 3 to 4 hours and the reminder over 24 hours. https:// In severe metabolic acidosis, bicarbonate may be given to correct the base deficit in the extracellular fluid within 24 hours.
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. **Note: treat hypokalemia or hypocalcemia first if present. Administer IV either undiluted or diluted in other IV fluid (50-1000ml) depending on fluid status. Labs: Bicarb[22-28], p H [7.35-7.45], p CO2 [35-45], p O2 [75-100], anion gap [12-14].