Moreover because of the discomfort and expense associated with endometrial biopsy, attention has turned to direct measurements of plasma progesterone levels as a means to rule out an inadequate luteal phase.
A single plasma progesterone level of 10 ng/ml in the luteal phase or a mean concentration of plasma progesterone of 12-13 ng/ml over 4 days at mid- luteal phase seems to exclude an inadequacy of corpus luteum function (3).
The technique is fairly easy to learn and may be performed without assistance.
Two hundred and thirty-two women with primary or secondary infertility were divided into four groups according to their endometrial biopsy result: 114 (49%) with no delay of the secretory phase, 36 (16%) with a secretory phase with a delay of 2 days, 26 (11%) with a secretory delay of 3 days or more, and 56 (24%) with an endometrium which could not be dated because of inadequate material. Secretory Phase and Implantation, Menstrual Cycle, Olena Ivanivna Lutsenko, Intech Open, DOI: 10.5772/intechopen.81304. Secretory Phase and Implantation, Menstrual Cycle, Olena Ivanivna Lutsenko, Intech Open, DOI: 10.5772/intechopen.81304.Speed points out that in women with suspected luteal phase deficiency, ideally endometrial biopsy should be carried out (1). The procedure is often performed to exclude the presence of endometrial cancer or its precursors .
Office endometrial suction catheters are easy to use, and several have been reported to have diagnostic accuracy that is equal or superior to the dilatation and curettage (D&C) procedure.
If you have endometrial cancer or are close to someone who does, knowing what to expect can help you cope.